The owners of Spiro's Mediterranean and Greek Restaurant have been a part of the Spiro's Family history since we were kids. our parents, Bill and Bessie Stratos.believed that everyone in the family had something to contribute to its success. We started doing small chores, bussed tables, then served as wait staff before becoming part of management. With our father's death, we became the managers and are dedicated to upholding the family tradition of outstanding quality food and service that was instilled in us by our family.
All together there are five restaurants in the St. Louis area that have a direct tie to the Karagiannis family.  The original Spiro’s on Natural Bridge which was started in 1977 by our uncle, Spiro.  Our restaurant, Spiro’s South,was established shortly after that and has been serving St. Louis for almost 30 years.  We grew up working in the restaurant and now our children are learning the special recipes and hospitalities that make Spiro’s on Watson one of the finest restaurants in St. Louis.

We  make everything we serve right here, in our kitchen. When you eat with us we treat you like family. Most items are cooked to your specifications. We believe that a meal at Spiro's should be a pleasant and relaxing experience and that
 patience is a virtue that makes for a wonderful meal.

While you wait for your perfect entrée, you will enjoy a serving of warm homemade breads and butter. Ask your server to prepare saganaki (or flaming cheese) at your table. You’ll be served a delicious goat cheese, doused with brandy and set on fire. Get ready to yell, “OOOMMMPPAH!”as the flames leap high into the air.  Sprinkle it generously with fresh lemon and enjoy!

 From lamb chops to steak Diane, you will find our entree menu varied and delightful. Even a vegetarian can find plenty of delicious selections at Spiro’s and, if you don’t find exactly what you want, just ask for something special from the chef’s menu.